Methods

animal models ;  behavioral testing ;  immunocytochemistry ;  postmortem brain ;  tissue culture ;  transcriptomics  

Topics

cellular neuroscience ;  cerebellum ;  genetics ;  glia ;  neurodegenerative diseases ;  neurological disorders  

Research Contributions

Differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in spinocerebellar ataxia type 1

PNAS (2022)

Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1

bioRxiv (2021)

Microglia regulate brain progranulin levels through the endocytosis-lysosomal pathway

JCI Insight (2021)