Joerg Bewersdorf, PhD

The Bewersdorf laboratory develops new super-resolution light microscopy approaches to reveal the nanoscale organization of cells and tissues for biomedical research. Current research efforts focus in particular on pushing the boundaries of multicolor and 3D imaging as well as the throughput, robustness, and quantitative nature of technologies such as DNA-PAINT and pan-Expansion Microscopy. The goal of these developments is to extend the application range of super-resolution microscopy and thereby enable microscopic perspectives on health and disease that were previously out of reach. In collaboration with a diverse set of research groups at the Wu Tsai Institute at Yale University and beyond, the research group applies its new techniques to current biomedical questions, including the organization of organelles and subcellular structures, for example, in neurons. Another important area of applications centers on the sub-cellular organization of tissue, in particular the anatomical and molecular basis of how neurons in the brain are interconnected ('molecular connectomics').

deep learning ;  multimodal imaging ;  optical imaging ;  superresolution imaging  

cellular neuroscience ;  circuits ;  connectivity ;  machine learning ;  neurons ;  synapses ;  biomedical image analysis  

Bewersdorf is the Harvey and Kate Cushing Professor of Cell Biology and Professor of Biomedical Engineering and of Physics at Yale University. He received his diploma (1998) and his doctoral degree in physics (2002), training with Stefan W. Hell at the Max Planck Institute for Biophysical Chemistry in Goettingen, Germany. After four years at The Jackson Laboratory in Bar Harbor, Maine, he relocated his research group to Yale University in 2009.