Z. Jimmy Zhou, PhD

Areas of interest: visual signal processing and computation in the retina, retinal physiology and neuronal circuitry, visual system development, retinal organoids Experimental approach: electrophysiology, two-photon imaging, optogenetics, visual stimulation and modeling Areas of interaction with WTI mission: Neuro (visual) cognition and behavior, neuro (visual system) development, neuro (retina) computation

calcium imaging ;  electrophysiology ;  optogenetics ;  organoids ;  patch clamping ;  two-photon imaging  

circuits ;  connectivity ;  physiology ;  sensory sytems ;  synapses ;  vision  

My lab has been studying visual physiology, retinal circuitry, and visual system development for over two decades. Our current studies focus mainly on correlating physiological function with the recently well-described connectomic and transcriptomic properties of the retina. We combine electrophysiology with optogenetics, two-photon imaging, and molecular manipulations to understand visual computation in a functional intact retinal preparation. Using the same approach, we are also investigating neural function and circuitry in retinal organoids and animal models of ocular diseases.