
Using computation for neuroactive small molecule synthesis
The Newhouse Group's research centers on technology development for synthesizing small-molecule natural products and analogs that perturb neuronal function. Many molecules exhibit exciting properties but are only available in trace quantities from natural sources or via conventional synthetic organic methodology. Instead, detailed physical organic studies using computational approaches facilitate the development of construction reactions, which are used to simplify access to neurologically active probe compounds for receptor imaging, cellular and molecular mechanism of action studies, and the development of novel pharmaceuticals.
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Biography
Tim Newhouse completed his undergraduate studies at Colby College in 2005, mentored by Dasan M. Thamattoor. He earned his PhD in 2010 from The Scripps Research Institute under Phil S. Baran and Donna G. Blackmond. After postdoctoral research with E.J. Corey at Harvard, he joined Yale University in 2013 and is now a Professor in the Department of Chemistry. His research focuses on chemical technologies and computational approaches to enable step-efficient synthesis of neuroactive small molecules.